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[89] indicated that 2M was increased in COPD patients and was correlated with lower pulmonary diffusing capacity values, increased alveolar wall/septal thickening (fibrosis changes), and higher expressions of TGF-1, Smad4, and a-SMA

This includes the wrapper, which Eiroa said is naturally darker because of the amount of sun and nutrients it receives, as opposed to wrappers that are dark simply because of their origin or how they are processed