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However, researchers had started to formally document the connection between smoking and lung cancer as early as the 1930s

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10, n o 2, ISSN 1932-6203, DOI 10.1371/journal.pone.0116861, lire en ligne, consult le Matthew C

443 It was first recorded in California in the late 19th century, although how it was introduced is unclear

Determining the optimal number of puffs per day hinges on understanding the correlation with cigarettes

(j) On packages containing less than 4 pounds or 1 gallon and labeled in terms of weight or fluid measure: (1) The declaration shall be expressed both in ounces, with identification by weight or by liquid measure and, if applicable (1 pound or 1 pint or more) followed in parentheses by a declaration in pounds for weight units, with any remainder in terms of ounces or common or decimal fractions of the pound (see examples set forth in paragraphs (m) (1) and (2) of this section), or in the case of liquid measure, in the largest whole units (quarts, quarts and pints, or pints, as appropriate) with any remainder in terms of fluid ounces or common or decimal fractions of the pint or quart (see examples in paragraphs (m) (3) and (4) of this section)