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On the basis of the current evidence Reference Talati, Bao, Kaufman, Shen, Schaefer and Brown6,Reference Thomson, Berk, Dodd, Rapado-Castro, Quirk and Ellegaard7,Reference Slyepchenko, Brunoni, McIntyre, Quevedo and Carvalho9 and a strong genetic correlation between bipolar disorder and schizophrenia, Reference Ruderfer, Ripke, McQuillin, Boocock, Stahl and Pavlides11 we hypothesised that smoking is a causal risk factor for bipolar disorder

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Similarly, a study of US military personnel deployed near Iraq from March 2003 to March 2004 identified 18 AEP cases among 183,000 soldiers, primarily affecting young male smokers, many of whom had recently started smoking [19]

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