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Chronic inflammatory responses happen much later, perhaps through uptake and metabolism (bioactivation) of NNK/nicotine in macrophages (Figure 2)

Its more of a hypothetical argument thats often made when talking about e-cigarette use in young people, but no data supports the theory, and it defies biological plausibility, he says

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When you place the snus portion under your lip, it releases the nicotine

Suitable for daily use