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D.TakahashieN.et al (2014)

J., Wang, K

Int J Womens Dermatol

The therapeutic dose is approximately 300-fold below the toxic threshold according to animal studies

Abbreviations ALSFRS-R: Revised amyotrophic lateral sclerosis functional rating scale CSF: Cerebrospinal fluid Cys: Cysteine GSH: Reduced glutathione GSH*: Glycine- 13 C 2 , 15 N-Glutathione tGSH: Total glutathione GS-NEM: Derivatisation of GSH by NEM tGS-NEM: Derivatisation of tGSH by NEM GSSG: Oxidised glutathione HC: Healthy control group HPLC: High-pressure liquid chromatography ALS: Amyotrophic lateral sclerosis MRM: Multiple reaction monitoring MS: Mass spectrometry NEM: N-Ethylmaleimide TCEP: Tris(2-carboxyethyl)phosphine References Barber SC, Mead RJ, Shaw PJ

In Singapore, the use of intravenous whitening drips is prohibited due to several associated risks: The Ministry of Health and the Health Sciences Authority have not endorsed these treatments, and their use is considered non-compliant with local medical regulations