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By the 1970s, some brands of light cigarettes contained more tar and nicotine than full-flavor cigarettes (whose own tar and nicotine levels had been decreasing)

[51] A 2014 in vitro study demonstrated that e-cigarette use of a "balsamic" flavor with no nicotine can activate the release of proinflammatory cytokine in lung epithelial cells and keratinocytes

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Starting in the late 1930s, scientists began making connections between cigarettes and public health risks