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PMID 30114238

0.5% Tranexamic Acid - helps fade discoloration, soothes redness, and improves microcirculation

Single-agent therapy typically serves as the first-line approach before considering combination strategies

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Inhibition of COX-2 by NSAIDs blocks PG production at sites of inflammation, whereas inhibition of COX-1 in other tissues (platelets and the gastroduodenal mucosa) leads to common adverse effects of NSAIDs, such as bleeding and gastrointestinal ulceration ( Owing to the adverse effects of NSAIDs and corticosteroids, disease-modifying antirheumatic drugs (DMARDs), a class of immunosuppressive and immunomodulatory agents, are developed to prevent and relieve RA aggression

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