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V.TanakaK.WaditeeR.OshimiS.MatsuzakiY.FukuharaM.et al (2006)

It suppresses activation of the TLR4/NF-B signaling pathway and downregulates proinflammatory cytokines

maintenance phase is the heavy draw 26 weeks 13 vials Standard Phase 2 duration 32 weeks 16 vials Phase 2 T2D study duration 68 weeks 30 vials REDEFINE 1 / REDEFINE 2 endpoint duration Peptide Vials (10 mg vial, 2.4 mg/week target) Each 10 mg vial covers about 4 weekly doses at 2.4 mg/week

Since exenatide has dose-dependent effects77), after 1 month of drug administration, patients should be injected with 10-g doses1)

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This is particularly valuable for addressing genes with defective proteins that are difficult to be targeted with conventional drugs, showing considerable potential in treating rare, chronic, infectious diseases and other metabolic disorders