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Glutathione plays a direct role in the production of melanin
Genetic variability: Polymorphisms in UGT/SULT/GST/CYP2E1 influence NAPQI clearance
Once reconstituted, it must be stored in the refrigerator
In addition to the disparity between the countries of origin of the articles, most commonly from Brazil, Mexico and Chile, it was observed that the studies did not always include a sample representative of the ethnic composition of their country
Critical limitations identified in the systematic review include predominant use of small rodent models (primarily rats), short follow-up periods relative to human healing timelines, variable dosing regimens complicating dose-response assessment, and lack of standardized outcome measures across studies
2021;16(1):e0245079
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