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The second approach uses a mode of action (MOA), and human relevance framework for weighing the evidence has been applied (Supplementary Table 3, available online), which has evolved for risk assessment purposes from causation criteria developed in the 1960s by Sir Austin Bradford Hill (38), where more recent considerations now are applied in the context of modern scientific principles and specific defining questions (39,40)

Meta-regression could not be performed in prevalence of smoking calculation due to lack of basic population data in every included study

Nicotine, a key ingredient in e-cigarettes, is a chemical that typically raises ones blood pressure and heart rate, putting strain on the heart which can result in cardiovascular disease

In fact ETS increases risk of death by 20 to 30% for non-smokers married to smokers

As you might have guessed it, the devices were a hit because they offered the right tool for the right person

The story behind the ad is anything but