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Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 1228 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses

The conversation about these medications needs to include realistic expectations about long-term use

Although well tolerated, over consumption of cinnamon may cause hepatotoxicity (liver damage) in humans and animals