Growth hormone secretagogue combination for pulsatile release studies
PMID: 38737002 | DOI Look M, Dunn JP, Kushner RF, Cao D, Harris C, Gibble TH, Stefanski A, Griffin R
It is believed to work through multiple pathways, including: Blocking voltage-gated sodium channels , reducing neuronal excitability Enhancing GABA (gamma-aminobutyric acid) activity , an inhibitory neurotransmitter Antagonising glutamate receptors , further dampening excitatory neurotransmission Inhibiting carbonic anhydrase enzymes , though the clinical significance of this effect is uncertain While topiramate's primary indications are epilepsy and migraine prophylaxis, it has been observed to cause weight loss as a side effect, likely through appetite suppression and altered taste perception
Rapid weight loss leading to telogen efluvium is a known phenomenon, having been identified in many weight loss situations, including crash dieting and bariatric surgery
[1] Women using oral contraceptives should use additional contraception for 4 weeks after starting Mounjaro and after each dose increase
The relatively short washing period (20 min) between the two stimulations could explain this, as molecular sensors involved may have been saturated or desensitized by the first stimulation by the time of the second stimulation
