17 Screening should be considered in patients with risk factors, and diagnostic testing should be considered in those with suspected clinical manifestations
Sometimes they are very intense
Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)
Great for detecting early coronary artery disease
Moretti IF, Lerario AM, Sola PR, Macedo-da-Silva J, Baptista MDS, Palmisano G, et al
For example, Yuancheng Lu, a graduate student who worked under David Sinclairs supervision, had the task of testing dozens of genes to find if any could restore epigenetic information to potentially rewind the clock on aging