Clinical effectiveness of currently used antidepressant drugs, which target monoaminergic systems in the brain mainly by enhancing serotoninergic and noradrenergic neurotransmission, is very often low and insufficient since approximately only one-third of the patients achieve complete remission of depressive symptoms after therapy
For example, B Vitamins are essential for energy metabolism, ensuring your immune cells have the "fuel" they need to multiply and fight
At the same time, more of your existing NAD+ gets consumed by enzymes like CD38 and PARPs, which are activated by things like inflammation, oxidative stress, and DNA damage
This years Namgok lecture covers the impact of current anti-diabetic medications on pancreatic -cell sensitivity to glucose and incretin hormones
GSH is at 110 mM concentrations in all mammalian tissues (highest concentration in liver) as the most abundant non-protein thiol that protects against excessive oxidative stress
Lund AM, et al
