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Our study confirmed that SFN can be effective against cutaneous inflammation in an IMQ-induced psoriatic mouse model, consistent with previous findings of its therapeutic effects in chronic inflammatory diseases such as inflammatory bowel disease, respiratory diseases, and rheumatoid arthritis [35]

Higher, levels of betaine were also observed in the plasma, liver, and brain in females compared to males

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Pathogen-associated molecular patterns (PAMPs) released by sepsis-inducing microorganisms activate pattern recognition receptors (PRRs) expressed by various immune cells and trigger a strong innate immune response