Comprising the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, it lacks the central dipeptide Ala-Trp found in growth hormone-releasing peptide (GHRP)-1
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It binds the GHRH receptor on pituitary cells and works through the Gs protein and cyclic AMP pathway, as outlined in a review of growth hormone secretagogues
[DOI] [PMC free article] [PubMed] [Google Scholar] 92.Thomas SJ, Morimoto K, Herndon DN, Ferrando AA, Wolfe RR, Klein GL, Wolf SE