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Nicotine and other chemicals in cigarettes and cigars can increase anxiety

The FDAs decision on ZYN, whose manufacturer, Swedish Match, had applied for authorization in 2020, was long overdue, says Jasjit Singh Ahluwalia, a physician and public health scientist at Brown University, who has studied nicotine addiction for more than 30 years

Nat Rev Cancer 2003

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We might look towards smokeless tobacco products such as snus to give an indication of potential side effect of a product being held against the oral tissues for prolonged periods