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Experimental studies have demonstrated that acute e-cigarette use raises blood pressure and heart rate through nicotine-mediated sympathetic activation [17, 18]

In the hope and expectation that the research project proposed will aid materially in finding solutions to public health problems of national and international concern, the undersigned companies are willing to contribute to the American Medical Association Education and Research Foundation for use in financing the research project during the period 1964 through 1968 a total of $10 million

To investigate the underlying mechanisms, we performed subsequent in vivo and in vitro experiments

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