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[26] [27] Some electronic cigarettes contain synthetic nicotine analogues (for example, 6-methyl nicotine, sometimes marketed under the trade name "Metatine") [28] and makers are trying develop nicotine substitutes

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doi:10.1001/jamanetworkopen.2018.3535

This downward trend has continued, nearly halving cigarette sales in just seven years: from 180 billion cigarettes sold nationwide in 2015 to under 100 billion in 2022, according to industry sales reports