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A combination therapy of short-acting (nicotine gum, lozenge, inhaler, or spray) with long-acting (nicotine patch or bupropion SR) can be used in the case of patients who remain refractory to monotherapy ( 87 )

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, MCI, dementia) are sporadic, this suggests that environmental factors like tobacco smoke might play an important, but undefined, role in their etiology (Ourry et al., 2024