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Nicotine profoundly disrupts the sleep-wake cycle by altering the activity of neurotransmitters such as acetylcholine, dopamine, and norepinephrine, which regulate arousal and the brain's reward systems

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Interestingly, these changes worsened after quitting smoking, with a drop in sex hormone-binding globulin (SHBG) noted as early as the first week of non-smoking

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