Risk of bias assessment Overall risk of bias for all RCTs was determined to be high, with some concerns in two studies, and low in the remaining three randomized studies (Appendix B)
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404 Topiroxostat Topiroxostat, a nonpurine xanthine oxidase inhibitor, interacts with multiple amino acid residues within the solvent channel and forms covalent bonds with the molybdenum ion
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