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None of those mechanisms directly break down skeletal muscle

In addition to increasing uric acid excretion, it inhibits the production of IL-1, thereby reducing the occurrence of flare gout (Shahid and Singh, 2015)

Beyond 6 months Long-term data from the SURMOUNT trials show continued weight loss up to 72 weeks, with average total weight loss reaching 20.9% on the highest dose (15 mg) 3

Research points to a likely decline in orthopedic surgery volumes in the years ahead due to these weight loss benefits, though short-term spikes may occur as more patients qualify post-weight loss

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GLP-1 receptor agonists like semaglutide have documented anti-inflammatory effects