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29 September2012 2

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Jiang HJ, Wu FL, Chen SL, Qiu GJ, Ma Y

A similar study in the US yielded the same reduction in biomarkers of potential harm 101

Figure 1 Decreased RNA expression levels of immune checkpoints, such as TIGIT, CTLA-4, and BTLA were observed in epithelium obtained from nasal scrape biopsies of self-described active e-cigarette users compared with samples from non-smokers ( In vitro analysis indicated that exposure of human neutrophil to e-cigarette aerosols impaired migration, phagocytosis, oxidative burst response, extracellular trap formation, and induced changes in PD-L1 expression

Another treatment option that has shown great promise is the drug Rybrevant, which is approved by the U.S