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The format is flexible, but the protein anchor is non-negotiable
Amongst the approved ICI agents, anti-PD1 agents have the largest indication across several tumours, including metastatic non-small cell lung cancer (NSCLC) [4], advanced head and neck cancer (HNC) [5], advanced melanoma [6], genitourinary tumours and others [7, 8]
Particularly, MUFAs (oleic acid) can compete with PUFAs (arachidonic acid, linoleic acid) for incorporation into phospholipids to exert anti-ferroptotic effects (68, 69)
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The calories in / calories out model oversimplifies whats actually a complex and sensitive system
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