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No concrete evidence of exactly what they smoked exists, but the most probable theory is that the tobacco was much stronger, consumed in extreme amounts, or was mixed with other, unknown psychoactive drugs

2005;139(C):2430

The ban will likely mean more unsightly cigarette butts on sidewalks and in gutters

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The insula ties in with those systems and could be a key part of the pathway that sets people up for relapse should they try to quit