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In cell and mice studies, butyrate also affects gene expression and cell signaling in ways that could reduce development of colorectal cancer

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DIO mice were placed into metabolic cages 2 days prior receiving the first dose of G49 and metabolic parameters were recorded for the following 3 days

The weight-loss effect of GLP-1RAs also benefits NASH improvement, by reducing appetite and increasing energy expenditure to promote weight loss, thereby indirectly ameliorating NASH