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Padro and Sanders, 2014) and is causally related to the development of chronic subclinical inflammation ( 3.9 SNS and RAAS The SNS and the RAAS interact with each other in the form of a positive feedback loop: NE activates ANG II production by stimulating renin secretion, whereas circulating ANG II interacts with the SNS and potentiates NE release from sympathetic nerve terminals (Saxena, 1992