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Abnormal HPA axis signaling can cause persistent cortisol increase, causing oxidative stress via many mechanisms, including mitochondrial dysfunction and endoplasmic reticulum stress (54)

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inhibit growth, biofilm formation and gene expression of caries-inducing Streptococcus mutans

W., Grusdat, M., Duncan, G

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However the short-term efficacy of such corticosteroid injections has been documented in several prospective, randomized studies