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Net of covariates, including gender, age, marital status, years of schooling, hukou type, income, and employment status, the serial mediation model in Table 4 indicates an overall positive association between tobacco dependence and chronic disease risk (total effect, STDYX=0.051

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Undoubtedly, larger studies with longer observation and more laboratory work that aims to unravel the mechanism of immune alteration by cigarette smoke are required to address this complex phenomenon

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