Provide specific instructions for insulin dosing, sliding scales, and oral agent management in the setting of variable PO intake and stress hyperglycemia
Tirzepatide belongs to a new class of medications called dual incretin receptor agonists
The diabetes-induced reduction of neurogenesis in the hippocampal dentate implies a potential mechanism for diabetes-related cognitive decline.105110 A possible explanation is that pro-inflammatory factors in type 2 diabetes compromise endothelial caveolin-1, a major membrane intrinsic protein in the caveolae on the cell surface, leading to vascular dysfunction, affecting neurogenesis, and subsequently leading to AD.111 IKK/NF-B-mediated impairment112 and -aminobutyric acid and glutamate transporter systems113 may also be involved in diabetes-induced damage of neurogenesis
Ness JK, Wood TL (2002) Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosis
Th17 cells, producing IL-17, IL-21, and IL-22, drive local inflammation, recruit neutrophils, and stimulate fibroblasts and epithelial cells, contributing to tissue damage
References: FARXIGA (dapagliflozin) [package insert]
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