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Previous studies have shown that, compared with never-smokers, current smokers have an OR of 3.51 (95% CI: 3.083.99), and former smokers have an OR of 2.89 (95% CI: 2.633.17) for COPD risk, with smoking duration being a key factor (33, 34)

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Similarly, in the context of smoking, nicotine appears to have no effect on thrombo-hemostatic features such as platelets or t-PA, PAI-1, or fibrinogen (31, 58)

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