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2022 Feb;47:707

Recent studies further confirmed 5-OH-PA as the most toxic metabolite, causing liver damage and metabolic shifts in rats (Rawat et al., 2018

Johnson JB, Summer W, Cutler RG, et al

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By the way, GS also tries to guesstimate the impact of other health innovations, and calculate a combined impact with obesity drugs: advances in computational biology, the advent of big data in healthcare, and a greater understanding of human genomics (via the Human Genome Project and a lower cost of sequencing)which have spurred innovations in areas such as AI-powered drug discovery, gene editing, improved immunotherapy, better diagnostics, and the development of more affordable biosimilar drugscould accelerate health improvements