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About 870,000 youth used disposable e-cigarettes in 2020, which was a large increase from 2019

80 E-cigarettes The EU Tobacco Products Directive, which came into force in 2016, restricts the promotion and advertisement of e-cigarettes in all EU Member States

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Heavy smokers defined by prediagnostic circulating cotinine levels had a multivariable-adjusted HR for death of 1.76 (95% CI, 1.23 to 2.51) compared with nonsmokers