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[10] TMG can help replenish methyl groups and facilitate the clearance of nicotinamide, theoretically reducing the buildup of by-products that could cause fatigue or headaches in some individuals

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"MOTS-c can significantly enhance physical performance in young, middle-age, and old mice." Reynolds et al., Nature Communications , 2021 [3] The ceiling on all of this is the same ceiling every mitochondrial peptide hits: the outcome data is rodent data