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Current medicinal chemistry , 31 (29), 4579-4601

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doi: 10.1159/000264392 120 RitterRC

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Run one, not both

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You might notice excessively large thighs and cylindrical legs with a sharp cut-off at the ankles, frequently referred to as the cuff-sign. The hands and feet usually remain completely unaffected, though some patients develop painful fatty nodules around their ankles

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The most commonly reported adverse events (observed in greater than 5% of clinical trial participants) were nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection-site reactions, fatigue, hypersensitivity reactions, eructation, hair loss and gastroesophageal reflux disease

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