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Activation of Beclin 1 is responsible for the production of phosphatidylinositol 3-phosphate (PI3P), which is necessary for the formation of autophagosomes (Racanelli et al., 2020), which regulates the formation of autophagosomes by recruiting protein factors, including WD repeat domain phosphoinositol-interacting protein (WIPI-1/2

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This work is primarily supported by internal grant from the Los Alamos National Laboratory (LANL), specifically the Laboratory Directed Research and Development (LDRD) grant (0240803ER: A Living Diagnostic-Therapeutic System) awarded to RJ and AK

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