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(1) Controlled-Release PHEN/TPM in Severely Obese Adults (EQUIP) trial (obesity without comorbidities), (2) Controlled-Release Phentermine plus Topiramate Combination in Overweight and Obese Adults (CONQUER) trial (obesity with comorbidities), and (3) SEQUEL (2-year extension of CONQUER), were comprised of 7% of older adult participants across the trials, although the upper age limit was 70 [111,112,113]

Typical dosages for glutathione supplements range from 250 to 1,000 mg per day, but individual needs may vary

Headache represents another occasionally reported effect, potentially related to the peptide's vasodilatory properties

Takeda T, Azumi J, Masaki M, Nagasawa T, Shimada Y, Aso H, et al