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Based on non-clinical and clinical data, in 2021, Lee proposed a hypothesis that GLP-1 receptor agonists could be potential therapeutic candidates in pulmonary hypertension patients recovering from COVID-19 by regulating the right ventricular systolic pressure and pulmonary artery remodeling [87]

Peptide drugs like tirzepatide are protein-based

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While head-to-head comparison is lacking, CagriSema seems more effective in promoting weight reduction than the dual agonist of GLP-1R and gastric inhibitory polypeptide (GIP) receptor, tirzepatide (table 2)

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Population: 97.8% Asian, 93% male, mean weight 76.7 kg, mean BMI 26.3, healthy non-diabetic