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Medication may reduce nerve excitability, but pain can continue if there is ongoing vascular compression, peripheral branch irritation, dental-related nerve trauma, postherpetic nerve injury, muscle spasm, scar tissue, local inflammation, or central sensitization

[DOI] [PubMed] [Google Scholar] 67.Shibata K., Kawada T., Iwai K

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Some combinations may require modified application schedules or concentrations