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Conclusion The analysis in this paper shows that many of the toxins in cigarette smoke increase substantially when additives are put in cigarettes, including the level of TPM, and that, assuming that the toxicological results from Project MIX represent unbiased estimates of the true biological effects, these data show many adverse biological consequences (and that the failure to reach statistical significance was the result of underpowered studies rather than lack of an effect)

First, the results of the included studies are heterogeneous and did not allow to perform a meta-analysis

& Tatara, K

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Front Chem

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