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E-cigarettes or vaping devices of any kind are not safe for use by youth, young adults, or pregnant/breastfeeding women
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References Florisa-Leila Ramos
Among men, the pooled relative risk for coronary heart disease was 1.48 for smoking one cigarette per day and 2.04 for 20 cigarettes per day, using all studies, but 1.74 and 2.27 among studies in which the relative risk had been adjusted for multiple confounders
They are legal under federal law, though state and local regulations vary
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