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doi:10.1038/jid.1967.24

Scientists have found that this T cell reduction in HIV-positive individuals stems from a decrease in enzymes responsible for GSH synthesis in the body

While topical forms may not deliver the same potency, they offer a non-invasive option

Biochem Biophys Res Commun 305:484487 Saito M, Soshi S, Tanaka T, Fujii K (2004) Intensity-related differences in collagen post-translational modification in MC3T3-E1 osteoblasts after exposure to low- and high-intensity pulsed ultrasound

No reason to expect significant rebound or withdrawal