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This leads to the classic signs of aging: fine lines, wrinkles, and a loss of firmness

JAMA 2017;318:360-70

Serious side effects are rare when treatment is supervised by a qualified professional

[93] Veterinary patients with the condition share many of the same clinical signs as their human counterparts, including progressive exercise intolerance, increased respiratory rate, and eventual respiratory distress

The HRH2 gene is also expressed in additional cells of the gastrointestinal tract, cells of the central nervous system, smooth muscle cells, endothelial cells, and cardiomyocytes

FOXO transcription factors as mediators of stress adaptation