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[3] They would grind their tobacco leaves using a mortar and pestle made of rosewood, where the tobacco would also acquire a delicate aroma of the wood

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Drawing upon the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted three systematic reviews to capture all available peer-reviewed literature pertaining to chewing tobacco and five types of head and neck cancers, ischemic heart disease, and stroke