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doi: 10.1016/S1471-4906(01)01955-X 89 LiuMLiuJHaoSWuPZhangXXiaoYet al

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Later that same year the orforglipron structure (Kawai et al) showed the now-recognised Trp33 ECL1 anchor that underlies the human-receptor selectivity of the modern small-molecule series

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