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Using an untargeted NMR-based metabolomics approach combined with multivariate and statistical analyses, we identified significant metabolic alterations and assessed their diagnostic potential

For instance, the expression and activity of several NAD + -consuming enzymes (i.e., PARPs, CD38) in activated immune cells are frequently upregulated during inflammation [20, 21, 38, 82, 86, 87], thereby contributing to further NAD + depletion

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