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Ultra high concentration 10,000ppm Copper peptide GHK-Cu, concentration 1000ppm, is synthesized by combining peptide glycyl-histidyl-lysine with copper ion

Each has distinct mechanisms and clinical evidence bases

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The peptide may complement or potentially reduce reliance on proton pump inhibitors for ulcer management, though comparative effectiveness studies are needed

In phase 3 research, a gradual escalation over roughly 16 weeks to the maintenance dose of 2.4 mg was chosen to optimise tolerability NEJM, 2025