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New York: Oxford University Press

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Smoking a single cigarette during the controlled use period produced a predictable nicotine concentration-time curve, with a rapid peak nicotine concentration followed by a gradual elimination

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Clinical research has shown that e-cigarettes can cause oxidative stress, mutations, dysfunction of heart cells, inflammation of the blood vessels, dysfunction of the endothelium (inner lining of the blood vessels), vasospasm (narrowing of the blood vessels), aggregation of platelets and increased risk of blood clots , hypertension (high blood pressure), tachycardia (increased heart rate), stiffening of the arteries, atherosclerosis (cholesterol deposition in the arteries), and increased risk of myocardial infarction ( heart attack )