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Description

The slower titration protocols being used in Phase 3 trials may further reduce discontinuation rates by allowing more gradual adaptation

NT-proBNP: N-terminal proB-type natriuretic peptide

meeting any one tier is sufficient

Over several weeks, dark spots and uneven tone look softer and more even

Weeks 5 through 8 increase to 0.5 milligrams weekly, then weeks 9 through 12 jump to 1.0 milligram weekly, and the final phase continues 1.7 milligrams or reaches 2.4 milligrams based on clinical response and tolerability